StrongBad and Tycho have both been in video games .I kinda doubt it, Telltale describes "The Inventory" as a hangout for video game characters.
What if in the next Inventory game, they have Guybrush and/or Doc Brown. That would be sweet..... although I wonder if the Doc would fit the theme?
Then again, Tycho is from a comic and Strongbad is from a flash series, so I guess it's possible. I don't think it's very likely, though.
I just hope Telltale is able to throw in a bunch of super-surprising characters in future games. Like Professor Layton or something crazy like that.
Strong Bads cool game for attractive people
Penny Arcade Adventures.
Though, it'd be cool to get some more people surrounding video games, rather then in them.